Assessment of Components, Antibacterial and Antioxidant Effects of Vernonia Amygdalina Del.
Medical – Biological Research Center, Lamdong Medical College, Dalat City, Vietnam.
2Penn State Medical College, Hershey Medical Center, PA, USA.
3Pham Ngoc Thach Medical University, Ho Chi Minh City, Vietnam.
Abstract
Vernonia amygdalina Del. - Asteraceae family, is used traditionally to treat inflammation, pain, fever and cancer. This
study aimed to determine the bioactive composition of leaf extracts of Vernonia amygdalina Del. for evaluating the
antibacterial and anti-oxidant effects of these extracts. Analysis of the active ingredients in the aqueous extracts of
Vernonia amygdalina leaves showed the presence of pharmaceutical substances such as: tannins, flavonoids, saponins,
alkaloid, phenol, phytalate and oxalate. The results of determining the antibacterial activity of fresh and dried leaf extracts
with concentrations of 100%, 50%, 25%, 12,5%, and 7,5% showed that Staphylococcus aureus and Escherichia coli are
very sensitive to these extracts, especially the aqueous extracts. The antioxidant activity of Vernonia amygdalina leaf and
stem extracts at different concentrations was determined by the DPPH and β-carotene-linoleic acid method compared
with BHA, BHT, and quercetin. A positive correlation of radical scavenging activity (p value < 0.05) was observed in all the
extracts from Vernonia amygdalina by their electron transfer or hydrogen donating ability.
