Open Access
American Research Journal of Orthopedics and Traumatology
ISSN (Online): 2572-2964
DOI: 10.46568/arjot
Comparative study between the effect of systemic use versus local use of tranexamic acid on blood loss and transfusion requirement in knee joint replacement.
Abstract
Blood loss during total knee replacement (TKR) remains a significant concern. The purpose of this study is to
compare the effect of systemic use versus local use of tranexamic acid on blood loss and transfusion requirements
in total knee replacement. Tranexamic acid (TXA) is an effective hemostatic agent used for the reduction of
blood loss and transfusion. However, the safety profile of TXA remains in question due to a potential increased
risk of venous thrombosis.
Patients and methods: In this study, 80 patients underwent TKR, and were divided into two groups based on
whether they received a systemic tranexamic acid intra-operatively, or a local infiltration of tranexamic acid.
Groups were then compared for mean calculated total blood volume (TBV) loss, transfusion rates, and knee
range of movement.
Results: The groups were compared after TKA, and the results showed that Mean TBV loss was similar between
groups: systemic tranexamic acid use mean was 705 ml (281 to 1744), local use mean was 712 ml(261 to 2308)
(p = 0.929).
Conclusions: no statistical difference between the two groups on decreasing blood loss and transfusion
requirement in TKA.
compare the effect of systemic use versus local use of tranexamic acid on blood loss and transfusion requirements
in total knee replacement. Tranexamic acid (TXA) is an effective hemostatic agent used for the reduction of
blood loss and transfusion. However, the safety profile of TXA remains in question due to a potential increased
risk of venous thrombosis.
Patients and methods: In this study, 80 patients underwent TKR, and were divided into two groups based on
whether they received a systemic tranexamic acid intra-operatively, or a local infiltration of tranexamic acid.
Groups were then compared for mean calculated total blood volume (TBV) loss, transfusion rates, and knee
range of movement.
Results: The groups were compared after TKA, and the results showed that Mean TBV loss was similar between
groups: systemic tranexamic acid use mean was 705 ml (281 to 1744), local use mean was 712 ml(261 to 2308)
(p = 0.929).
Conclusions: no statistical difference between the two groups on decreasing blood loss and transfusion
requirement in TKA.
