Evaluation of Phytochemical Constituents and Sedative Activity of Passiflora Edulis Sims Extracts
1Medical – Biological Research Center, Lam Dong Medical College, DaLat City, Vietnam.
2Penn State Medical College, Hershey Medical Center, PA, USA.
Citation: Hung Tran – Quoc, Sy Duong-Quy, et al., “Evaluation of Phytochemical Constituents and Sedative Activity of
Passiflora edulis Sims Extracts”, American Research Journal of Pharmacy, Vol 6, no. 1, 2021, pp. 1-6.
Abstract
Passiflora edulis Sims, Passifloraceae is widely grown in Lam Dong, Vietnam for its fruit as a beverage. This study is an
attempt to explore the phytochemical constituents using the chemical reagents and evaluate the sedative, anti - anxiety
activity of ethanol and water extract of leaves and rhizomes using the elevated plus-maze model and dark - light box test
in mice. The phytochemical screening results showed the presence of alkaloids, tannins, phenolic compounds, flavonoids
in leaves and rhizomes of Passiflora edulis, and the leaf have more alkaloids and flavonoids than the rhizomes. Moreover,
treatment with the leaf extract significantly (p<0.001) demonstrated sedative, anti-anxiety activity as compared to vehicle
control, in which the activity of ethanol extracts was significantly (p<0.001) better than water extracts. In addition,
at dosage of 300mg/kg the leaf ethanol extracts showed significantly (p<0.001) lower than diazepam 2mg/kg. These
finding are an important factor in evaluating the pharmacological effects and orienting the process of preparing sedative
tea products using Passiflora edulis leaf grown in Lam Dong, Vietnam in the future.
