Open Access
American Research Journal of Cardiovascular Diseases
ISSN (Online): 2575-7601
DOI: 10.46568/arjcd
Exposure to High Levels of Noise Poses Hazards and Risks for Development of Hypertension and Heart Disease: Potential Roles of Unrecognized Ionized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor
1Department of Physiology and Pharmacology, 2Department of Medicine,
3The Center for Cardiovascular and Muscle Research,
4The School for Graduate Studies in Molecular and Cellular Science, State University of New York Downstate
Medical Center, Brooklyn, New York, USA, 5Bio-Defense Systems, Inc, Rockville Centre, New York, USA;
6The Magnesium for Health Foundation, Patterson , California
M. Altura B, Gebrewold A, Carella A, C. Shah N, T. Altura B. “Exposure to High Levels of Noise Poses
Hazards and Risks for Development of Hypertension and Heart Disease: Potential Roles of Unrecognized Ionized
Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor”. American Research Journal of
Cardiovascular Diseases. 1(1); pp: 25-34
Abstract
It has been demonstrated in numerous human and animal studies that audiogenic stress (AS) can
induce elevation of arterial blood pressure and cardiac damage and that noise –induced hearing loss may be
associated with alterations in magnesium (Mg) metabolism. Our laboratories, over a period of approximately
40 years, have been investigating why AS causes high blood pressure and cardiac damage. This review focuses
on a number of newer discoveries on why AS causes dysfunctions of the cardiovascular system (CVS) This
review discusses the pivotal physiological and biochemical importance of Mg to body health and the fact that
most Americans and Europeans are deficient in daily Mg intake which perforce can cause severe dysfunctions of
the CVS. Our ongoing studies clearly provide a solid microcirculatory basis for how and why AS above 65dB(A)
often induces elevated blood pressure and cardiac damage. We review a body of data that points to the fact that
AS does the latter, but appears to do so because noise stress levels result in Mg deficiency followed by release of
certain sphingolipids (e.g., ceramides) and generation and release of platelet- activating factor (PDF). It is our
opinion that all people exposed to high degrees of noise stress should be monitored for cardiovascular functions,
ionized Mg levels, blood ceramide levels and levels of PDF. Lastly, we believe all people exposed to high levels of
AS (i.e., maintenance people and pilots on aircraft carriers, musicians [particularly at rock concerts], motorman
and conductors on trains and subways, construction site workers, etc.) should have at least the equivalent daily
intake of 500-600 mg of Mg/day.
