American Research Journal of Cardiovascular Diseases

Background: Type 2 diabetes (T2DM) is a chronic and progressive disease that is strongly associated with all-cause and cardiovascular mortality. Oxidative stress plays a key role in both initiation and complications of T2DM. There is limitation in clinical studies have addressed the ideal exercise intensity that efficiently modulates the insulin resistance and abnormal oxidative stress markers among type 2 diabetic patients. Objective: The present study was designed to examine aerobic versus resisted exercise training effects upon insulin resistance and oxidative stress markers among type 2 diabetic patients. Material and Methods: One hundred obese patients with type 2 diabetes mellitus, their age ranged from 45-57 years and their body mass index ranged from 30-36 kg/m2 were equally assigned into 2 groups: The first group received aerobic exercise training in the form of treadmill aerobic exercises where, the second group received resisted exercise training for 12 weeks. Results: The mean values of Homeostasis Model Assessment-Insulin Resistance Index )HOMA-IR(,conjugated dienes (CD) and malondialdehyde (MDA) were significantly decreased, while the mean values of the quantitative insulin-sensitivity check index (QUICKI),glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were significantly increased in patients of group (A) as a result of aerobic exercise training and group (B) as a result of resisted exercise training. There were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment with more changes in patients received aerobic exercise training. Conclusion: The current study provides evidence that aerobic exercise is more appropriate than resisted exercise training in modulating insulin resistance and oxidative stress among type 2 diabetic patients.