American Research Journal of Hematology

Background: Bad obstetric outcomes are considered as major health problem with social and medical impact on society, with multiple etiology. Study Design: Descriptive Case Control Study. Aim: To evaluate the role of IL-6, IL-17 and angiopoietin in pregnancy loss in women in Kirkuk, Iraq. Materials and Methods: The study included 547 women with BOH and 291 women with normal pregnancy outcome. Serological study carried out to determine IL-6, IL-17 and Angiopoietin using ELISA kits. Results: IL-6 mean value was without significant difference among women with BOH , women with inevitable abortion and control. Pregnant BOH versus pregnant normal pregnancy, Non-pregnant BOH versus non-pregnant normal pregnancy, BOH versus normal pregnancy show significant differences in IL-6. IL-17 was with significant mean difference among BOH, abortion and normal pregnancy. Also, pregnant BOH versus pregnant normal pregnancy, BOH versus normal pregnancy, and abortion versus BOH show significant differences in IL-17. Angiopoietin was with significant mean difference among BOH, abortion and normal pregnancy. Pregnant BOH versus pregnant normal pregnancy, Non-pregnant BOH versus non-pregnant normal pregnancy, BOH versus normal pregnancy show significant differences in angiopoietin. Conclusion: Angiopoietin -1 appear to be an angiogenic predictive marker for women with bad obstetric history. A future study that included Ang-1, Ang-2 combination with others different biomarkers to determine their predictive value as a marker of BOH is warranted.