Re-examination on the Preparation of Topical Hydrogels Containing Human Umbilical Cord Mesenchymal Stem Cell Exosomes on a Rat Animal Model
United World College Changshu China,Suzhou, China.
Citation: Fei Xia, “Re-examination on the Preparation of Topical Hydrogels Containing Human Umbilical Cord
Mesenchymal Stem Cell Exosomes on a Rat Animal Model”, American Research Journal of Biosciences, Vol 8, no. 1,
2023, pp. 11-16.
Abstract
Full thickness skin defects and its treatments are fields where new critical challenges remain unsolved. Recent discoveries
on the therapeutic application of human umbilical cord derived exosomes (hUCMSCs) provides a new scope into
facilitating the wound healing effect. Beyond an effective loading, a natural hydrogel is further employed by multiple
studies. It is proved to extend the bioactivity of the exosomes and also to contribute the antibacterial and antioxidant
effect using hydrogel. The combination of hydrogel and hUCMSCs might provide synergy benefits. Herein, we established a
biocompatible, thermos-sensitive chitosan β-glycero-phosphate (CS/GP) hydrogel enclosing hUCMSCs which is performed
on rat cutaneous wound sites. The material preparation and characterization, exosome derivation and characterization,
and in vivo wound healing study are examined in this paper. The in vivo study demonstrates the effect of exosome and
hydrogel as effective wound-healing promoters individually, implied by a faster and higher wound reduction rate. The
study also shows that the effect of hydrogel loaded with exosome proves to need more clarifications and investigations to
maximize their influence on wound sites healing
