American Research Journal of Gynaecology

Background: A lower level of Anti-mullerian Hormone (AHM) is associated with reduced ovarian reserve and reduced chance of pregnancy with IVF treatments. Previous reports indicated that AMH should not be used as the criteria to exclude couples from performing additional IVF treatments.

Aim: The aim of the current study was to assess the outcome of IVF/ICSI in women with low circulating AMH level (< 1.3 ng/ml) and to examine the difference in IVF/ICSI outcome between women with low serum AMH (0.2-1.3ng/ml) and extremely low serum AMH (<0.2ng/ml).

Materials and methods: All patients who underwent an IVF/ICSI treatments with FSH stimulation in DR.Elsir Abu-Elhassan Fertility Center between 2016 and 2017 were between 20 to 49 years of age and had low serum AMH level (<1.3 ng/ml). In total 63 patients were analyzed cross-sectional retrospectively. Statistical analysis was performed with SPSS.

Results: All women underwent IVF/ICSI treatment, the success rate was 20.6% (13 women), among all women understudy serum FSH was significantly affected the success rate (p-value <0.05) women with high serum FSH tend to get not success ICSI.There was a low probability to get success ICSI in women with extremely low AMH (<0.2ng/ml) compared to women with low AMH (0.2-1.3 ng/ml), in women with extremely low AMH there was a lower number of oocytes retrieved , a lower number of fertilized oocytes and a lower number of transferred embryos .

Conclusion: AMH remains a good quantitative marker of the ovarian reserve but is a poor qualitative marker. Women with low (<1.3 ng/ml) AMH levels undergoing IVF/ICSI treatments still have reasonable chances of achieving a pregnancy