The Co-Evaluation of Ovarian Epithelium Karyorrhexis and Oophoritis after the Erythropoietin Effect on Ovarian Ischemia Reperfusion Injury
1*Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios” Thessaloniki, Hellas.
2Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Hellas.
3Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas.
4Department of Biologic Chemistry, Athens University, Athens, Attiki, Hellas.
5Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas.
6, 7, 8Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Hellas.
Citation: Constantinos Tsompos, Constantinos Panoulis, et al., “The Co-Evaluation of Ovarian Epithelium
Karyorrhexis and Oophoritis after the Erythropoietin Effect on Ovarian Ischemia Reperfusion Injury”. American
Research Journal of Biomedical Engineering. vol 2, no. 1: 1-8
Abstract
Aim: This study co-evaluated the 2 quoted histologic variables after the erythropoietin (Epo) administration.
The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic
variable of ovarian epithelium karyorrhexis (OK) or oophoritis (OI) in an induced ischemia reperfusion animal
experiment.
Materials and Methods: The 2 main experimental endpoints at which the OK and OI scores were evaluated was
the 60th reperfusion min(for the groups A and C) and the 120th reperfusion min (for the groups B and D). Specially,
the groups A and B were processed without drugs, whereas the groups C and D after Epo administration.
Results: The first preliminary study showed that Eponon significantly recessed the ovarian epithelium
karyorrhexis (OK) within the “without lesions alterations” grade by 0.0818182 [-0.2159977 - 0.0523614]
(p-value=0.2246)1. However, the second preliminary study showed that Epo significantly enhanced oophoritis
(OI) within the “without lesions alterations” grade by 0.1363636 [0.0421443 - 0.230583] (p-value=0.0057)2.
These 2 studies were co-evaluated since they came from the same experimental setting. This study investigated
the combined diagnostic value of both variables together.
Conclusions: Epo has a hardly deteriorating potency of these histologic parameters within the “without lesions
alterations” grade by 0.0272727 [-0.0556778 - +0.1102233] (p-value=0.5097) since they were co-evaluated
together.
