Mohamed Tawfik Gad Al-Rab, Emad MossaI brahim, Momen Mohamed Hassan, Dina
Hisham Hussain Emam Abdallah*
Objective: To evaluate the role of sonographic markers of ovarian morphology versus hirsutism indices in the
prediction of serum total testosterone in hirsute women
Study Design: Cross sectional observational Study.
Subjects: Eighty women (aged 18 to 40 years) form among the attendants of the Gynecology Clinic of Minia
University Hospital complaining of hirsutism were recruited into the Study in the period between January and
May 2017 after obtaining their informed consent.
Participants were evaluated regarding self-reported menstrual cycle history to determine the extent of any
menstrual cycle disturbance; male-pattern hair growth was assessed on nine regions of the body using the
modified Ferriman-Gallwey (mFG) scoringsystem, a transvaginal ultrasound scan to characterize ovarian
morphology and fasting blood sample for testosterone assay.
Main Outcome Measures: Regional and total modified Ferriman-Gallwey (mFG) scores, number of follicles
per follicle size category, follicle number per ovary (FNPO), ovarian volume (OV), ovarian area (OA), stromal to
ovarian area ratio (S/A), stromal echogenicity index (SI), total testosterone (TT) and menstrual cycle length.
Results: There were no correlations between any of the demographic characteristics of the study participants
and total testosterone.
There were no correlations between hirsutism scores and total testosterone of all study participants. However,
there were some association between hirsutism scores (upper lip, chin and lower abdomen) and total
testosterone of all study participants.
There were correlations between the three ovarian dimensions, ovarian volume, ovarian area, stromal
echogenicity and ovarian echogenicity and total testosterone. However, there were no correlations between
2-5 mm FNPO, 6-9 mm FNPO, 2-9 mm FNPO, stroma to ovary ratio & stromal echogenicity index and total
testosterone.
Conclusion: Sonographic markers particularly ovarian dimensions, ovarian volume, ovarian area, stromal
echogenicity and ovarian echogenicity are good predictors of total testosterone levels in women with hirsutism
whether having regular or irregular menstrual cycles. They are better predictor of total testosterone levels than
other Sonographic markers namely number of follicles of different sizes , stroma to ovary ratio and stromal
echogenicity index. They are much more sensitive predictors of total testosterone than hirsutism scores
whether regional or total scores.