American Research Journal of Pharmacy

T. Pham Viet1, P. Thai Phuong1, T. Bui-Viet1, A. Nguyen Thi Ngoc1, H. Tran Quoc2, S. Duong Quy2,3,4 

In the current pandemic of SARS-CoV-2, the fast development ofvaccines was mandatory due to many deaths and cases across theworld since the beginning of the outbreak. The European Medicines Agency (EMA) has allowed emergency use authorization for treatment with the Vaxzevria (ChAdOx1-S, AstraZeneca) vaccines in the European Union. There are a lot of adverse drug reactions observed during the vaccination campaign, the most common side effects are tenderness, pain and bruising at the injection site, headache, tiredness, muscle pain, general feeling of being unwell, chills, fever, joint pain and nausea (feeling sick), and can also rarely cause anaphylactic shock. The recognition of adverse drug reactions of the vaccine Vaxzevria plays an important role in minimizing vaccine-induced adverse reactions. In this report, we record and analyze a rare case of peripheral cyanosis appearing after being vaccinated, and sharing the way to resolve this problem to contribute to the data of adverse drugs reaction regarding Vaxzevria.

Hung Tran – Quoc1, Trinh Tang-Le-Quynh1, Nguyet Do-Thi, Chi Nguyen-Thi-Lan, Toi Nguyen-Van, Ha Le-Thi-Ngoc, Tram Tang-Thi-Thao, Anh Nguyen-Tuan, Ha Ngo-Duy-Tuy, Sy Duong-Quy1,2*

Passiflora edulis Sims, Passifloraceae is widely grown in Lam Dong, Vietnam for its fruit as a beverage. This study is an attempt to explore the phytochemical constituents using the chemical reagents and evaluate the sedative, anti - anxiety activity of ethanol and water extract of leaves and rhizomes using the elevated plus-maze model and dark - light box test in mice. The phytochemical screening results showed the presence of alkaloids, tannins, phenolic compounds, flavonoids in leaves and rhizomes of Passiflora edulis, and the leaf have more alkaloids and flavonoids than the rhizomes. Moreover, treatment with the leaf extract significantly (p<0.001) demonstrated sedative, anti-anxiety activity as compared to vehicle control, in which the activity of ethanol extracts was significantly (p<0.001) better than water extracts. In addition, at dosage of 300mg/kg the leaf ethanol extracts showed significantly (p<0.001) lower than diazepam 2mg/kg. These finding are an important factor in evaluating the pharmacological effects and orienting the process of preparing sedative tea products using Passiflora edulis leaf grown in Lam Dong, Vietnam in the future.

Sy Duong-Quy1,2,3, Trinh Tang-Le-Quynh1, Linh Nguyen-Thi-Nhat1, Linh Nguyen-Thi-Thuy1, Ha Ngo-Duy Tuy1, Tram Tang-Thi-Thao1, Toi Nguyen-Van1, Chi Nguyen-Thi-Lan1, Nguyet Do-Thi1, Ha Le-Thi-Ngoc1, Huong Cao-Thi-Thu1, Dinh Tran-Thanh1, Hung Tran-Quoc1*

Vernonia amygdalina Del. - Asteraceae family, is used traditionally to treat inflammation, pain, fever and cancer. This study aimed to determine the bioactive composition of leaf extracts of Vernonia amygdalina Del. for evaluating the antibacterial and anti-oxidant effects of these extracts. Analysis of the active ingredients in the aqueous extracts of Vernonia amygdalina leaves showed the presence of pharmaceutical substances such as: tannins, flavonoids, saponins, alkaloid, phenol, phytalate and oxalate. The results of determining the antibacterial activity of fresh and dried leaf extracts with concentrations of 100%, 50%, 25%, 12,5%, and 7,5% showed that Staphylococcus aureus and Escherichia coli are very sensitive to these extracts, especially the aqueous extracts. The antioxidant activity of Vernonia amygdalina leaf and stem extracts at different concentrations was determined by the DPPH and β-carotene-linoleic acid method compared with BHA, BHT, and quercetin. A positive correlation of radical scavenging activity (p value < 0.05) was observed in all the extracts from Vernonia amygdalina by their electron transfer or hydrogen donating ability.